Endocrine regulation and extended follow up of longitudinal growth in intrauterine growth-retarded rats
نویسندگان
چکیده
منابع مشابه
Endocrine regulation of longitudinal bone growth.
Longitudinal growth is primarily influenced by the GH-IGF-I axis, which is a mixed endocrine-paracrine-autocrine system. Further, classical hormones such as thyroxine, glucocorticosteroids and sex steroids play a role, as well as primarily paracrine systems. In the GH-IGF-I axis, seven disorders can be differentiated: (1) GH deficiency; (2) GHR defects; (3) defects in the GH signal transduction...
متن کاملCatch-up growth in intrauterine growth retarded rats: its correlation with histomorphometric changes of the pituitary somatotrope cells
The aim of the present study was to examine the long-term effects of prenatal injure on body and craniofacial growth in intrauterine growth retarded (IUGR) animals and its correlation with histomorphometric changes of the pituitary somatotrope population. IUGR model was carried out by means of uterine vessels ligation in pregnant rats at 14th day of pregnancy. Control and sham-operated animals ...
متن کاملLong-term follow-up of intrauterine growth restriction: cardiovascular disorders.
In the modern world, cardiovascular disorders are the leading cause of mortality in developed countries, which in most cases undergo a long subclinical phase that can last decades before the first clinical symptoms appear. Aside from the well-known risk factors related to lifestyle and genetics, there is growing evidence that in a proportion of cases, the predisposition to cardiovascular diseas...
متن کاملThe timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction.
Epidemiological studies demonstrated a relationship between low birth weight mainly caused by intrauterine growth restriction (IUGR) and adult metabolic disorders. The concept of metabolic programming centers on the idea that nutritional and hormonal status during the key period of development determines the long-term control of energy balance by programming future feeding behavior and energy e...
متن کاملHigh sodium intake increases blood pressure and alters renal function in intrauterine growth-retarded rats.
A suboptimal fetal environment increases the risk to develop cardiovascular disease in the adult. We reported previously that intrauterine stress in response to reduced uteroplacental blood flow in the pregnant rat limits fetal growth and compromises renal development, leading to an altered renal function in the adult offspring. Here we tested the hypothesis that high dietary sodium intake in r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2000
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.0.1660599